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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Neurotoxicology. 2011 Jun 29;32(5):563–566. doi: 10.1016/j.neuro.2011.05.019

Fig. 1.

Fig. 1

Pathways of regulation of MEF2 function by neurotoxins. Various neurotoxins modulate MEF2 activity through activating caspase and calpain/CDK5 pathways. H2O2, MPTP, 6-OHDA and 3-NP induce MEF2 oxidization through generating free radicals. Aβ, ethanol and cocaine modulate MEF2 activity through unidentified mechanism. APP enhances MEF2 function through p38MAPK pathway. O indicates oxidization; P indicates phosphorylation.