Table 3.
Multivariate Cox proportional hazard analysis of prognostic factors for mortality in 1,480 patients with HCV-related HCC, including serum AFP level at time of HCC diagnosis
| Adjusted Hazard Ratio (95% CI) | P-value | |
|---|---|---|
| AFP (ng/ml) at HCC diagnosis | ||
| <10 | Reference | |
| 10-<100 | 1.50 (1.22-1.83) | <0.0001 |
| 100-<1000 | 2.23 (1.80-2.76) | <0.0001 |
| ≥1000 | 4.35 (3.54-5.36) | <0.0001 |
| Not tested | 1.53 (1.26-1.86) | <0.0001 |
| Age | ||
| <50 | Reference | |
| 50-54 | 1.08 (0.90-1.29) | 0.45 |
| 55-59 | 1.03 (0.85-1.25) | 0.75 |
| ≥60 | 1.22 (1.01-1.47) | 0.04 |
| Sex | ||
| Female | Reference | |
| Male | 1.25 (0.65-2.42) | 0.51 |
| Race/Ethnicity | ||
| White | Reference | |
| Black | 1.05 (0.92-1.20) | 0.49 |
| Other | 0.95 (0.79-1.14) | 0.59 |
| Missing | 1.01 (0.79-1.29) | 0.93 |
| HCC Diagnosis | ||
| 1998-2002 | Reference | |
| 2003-2006 | 1.03 (0.89-1.18) | 0.71 |
| *Ascites | 1.74 (1.52-1.99) | <0.0001 |
| *Encephalopathy | 1.31 (1.11-1.54) | 0.001 |
| *CHF | 1.25 (0.96-1.61) | 0.09 |
| MELD | ||
| <15 | Reference | |
| 15-20 | 1.53 (1.27-1.84) | <0.0001 |
| >20 | 2.80 (1.98-3.94) | <0.0001 |
| Missing | 0.99 (0.86-1.13) | 0.83 |
| HCC treatment | ||
| Transplantation | 0.16 (0.10-0.26) | <0.0001 |
| Resection | 0.56 (0.42-0.74) | <0.0001 |
| TACE | 0.74 (0.64-0.85) | <0.0001 |
| RFA | 0.61 (0.49-0.77) | <0.0001 |
*
Within 1 year before HCC diagnosis