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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Trends Pharmacol Sci. 2011 Sep 8;32(11):666–674. doi: 10.1016/j.tips.2011.07.005

Figure 1. RGS14 domain structure and its identified binding partners.

Figure 1

Top: RGS14 directly binds activated Gαi family members and Gαo through its RGS domain, and it also specifically binds inactive Gαi1 and Gαi3 via its GPR domain. Activated H-Ras, Rap2, and Raf kinases directly interact with the Ras/Rap-binding domains (R1 and R2). Bottom: RGS14 is structurally and functionally unique in that it shares both an RGS domain and a GPR domain that places it and its closest relative RGS12 into both the RGS protein and the Group II AGS protein (GPR domain-containing) subfamilies.