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. 2011 Oct 5;31(40):14172–14181. doi: 10.1523/JNEUROSCI.2122-11.2011

Figure 1.

Figure 1.

Corticosterone and a GR agonist impair hippocampus-dependent emotional memory retrieval. A, B, Systemic corticosterone (Cort) disrupts retrieval of inhibitory avoidance and contextual fear. F(4,50) = 3.3 and p = 0.018 for the main effect of dose on avoidance (9–18 per group), and F(5,26) = 7.7 and p = 0.0001 for the main effect of dose on freezing (5–7 per group). For all figures: systemic injection occurred 30 min before testing 1 d after training unless stated otherwise, and *p < 0.05, ∧p < 0.01, #p < 0.001 for post hoc comparisons. C, Fluticasone, a GR agonist, mimics the impairment of contextual fear by cort. F(4,21) = 8.7 and p = 0.0003 for the main effect of dose (5–6 per group). D, Infusion of cort into the DH impairs contextual fear. F(4,21) = 10.6 and p < 0.0001 for the main effect of dose (5–6 per group). For all figures, DH infusions occurred 15 min before testing 1 d after training unless stated otherwise. E, cort impairment of contextual fear is rapid, suggesting a non-genomic mechanism. cort was infused 7.5 min before testing 1 d after training. F(1,8) = 3.54 and p = 0.008 (5 per group). F, Neither subcutaneous injection nor DH infusion of cort affects cued fear (5–8 per group, p > 0.6 for both).