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. 2011 Sep 13;8(1):13. doi: 10.1186/1559-0275-8-13

Figure 1.

Figure 1

"On-Strip" digestion method. In order to produce a peptide solution for MS-based proteomics analysis, we first dried oral epithelium to remove ambient saliva, then placed a PerioPaper strip on the location of interest (Oral Pre-Malignant lesion or normal oral epithelium) and allowed it to absorb exudate. The PerioPaper was next placed in trypsin solution for digestion of proteins to peptides for subsequent processing and mass spectrometry analysis. See Experimental Methods for details.