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Fluorination of 1 and 2 in the presence of different Lewis acids.
 | ||||
| Entry | Catalyst (mol %) | Conversion after 28 h (%) | ||
| 1→1-F | 2→2-F | |||
| neata | equilibratedb | |||
| 1 | none (“blank”) | 0 | 20 | 5 |
| 2 | Cp2Ti(OTf)2 (5) | 38 | >95 | 95 |
| 3 | Cp2Zr(OTf)2(thf) (5) | ≤2 | n.d.c | 8 |
| 4 | HBF4·H2O (10) | 24 | 47 | 47 |
| 5 | BF3·Et2O (10) | 11 | 31 | 22 |
| 6 | ZnF2 (5) | n.d. | 25 | n.d. |
aneat = substrate added in substance. bequilibrated = substrate added as stock solution in MeCN. cn.d. = not determined.
