Table 2.

Effect of catalyst loading, temperature, and water content on the fluorination of 1 with catalyst K1.^a

Entry	K1 (mol %)	T (°C)	Additives (mol %)	t (h)	ee (%)
1	1.2	rt		45b	25.2
2	5	rt		6	26.6
3	10	rt		2	26.5
4	20	rt		<2	25.5
5	50	rt		<0.3	23.4
6	100	rt		<0.3	22.4
7	5	rt	MS 3 Å	6	27
8	5	rt		6	28.5c
9	5	rt	H2O (5)	10	28.5
10	5	rt	H2O (50)	>12d	28
11	5	rt	H2O (1000)	–	–e
12	5	0		16	32
13	5	rt		<8	28
14	5	40		<2	23
15	5	60		0.1f	18

^aAll reactions were performed in reagent grade acetonitrile stored over 3 Å molecular sieves and run to complete conversion (TLC), unless otherwise mentioned. ^bReaction stopped before complete conversion. ^cEntries 1–6 vs 7–11 vs 12–15 were run with different batches of F–TEDA, solvent and catalyst, leading to small selectivity deviations under seemingly identical conditions. ^d50% conversion. ^eNo reaction. ^fConversion stopped at 80%.