Table 4.
Solvent effects on selectivity of fluorination of 6 with NFSI and K2.
 | |||
| Entry | Solvent | t (h) | ee (%) |
| 1 | MeCN | 40 | 84.5 |
| 2 | CH2Cl2 | 10 | 87.5 |
| 3 | THF | 18a | 77.5 |
| 4 | toluene | 24 | 85.6 |
a28% conversion.
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