Table 1.
Immunohistochemical Analysis of CD13 Expression in 149 Tumor Tissue Specimens
| Monoclonal Antibody |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM15 |
BF10 |
3D8 |
|||||||||||||
| Tissues | n | Vessels | Tumor Cells | Stroma | Adjacent Normal Tissues | n | Vessels | Tumor Cells | Stroma | Adjacent Normal Tissues | n | Vessels | Tumor Cells | Stroma | Adjacent Normal Tissues |
| Liver | |||||||||||||||
| Hepatocarcinoma | 2 | + | + | + | − | 0 | 0 | ||||||||
| Nodular hyperplasia | 1 | + | + | − | + | 0 | 0 | ||||||||
| Metastases of colon adenocrcinoma | 7 | ++ | − | + | + | 0 | 0 | ||||||||
| Metastases of melanoma | 1 | + | + | − | − | 0 | 0 | ||||||||
| Total | 11 | 11/11 | 4/11 | 9/11 | 8/11 | ||||||||||
| Bowel | |||||||||||||||
| Colon adenocarcinoma | 11 | ++ | − | + | − | 3 | +++ | − | + | +/− | 3 | +++ | − | + | +/− |
| Sigma adenocarcinoma | 1 | − | − | + | +/− | 0 | 0 | ||||||||
| Rectum adenocarcinoma | 1 | + | − | − | +/− | 0 | 0 | ||||||||
| Total | 13 | 12/13 | 0/13 | 12/13 | 0/13 | 3 | 3/3 | 0/3 | 3/3 | 0/3 | 3 | 3/3 | 0/3 | 3/3 | 0/3 |
| Breast | |||||||||||||||
| Ductal carcinoma | 8 | ++ | − | + | − | 0 | 0 | ||||||||
| Lobular carcinoma | 2 | + | − | +/− | − | 0 | 0 | ||||||||
| Intraductal carcinoma | 1 | + | − | + | − | 0 | 0 | ||||||||
| Undifferentiated carcinoma | 1 | + | − | +/− | − | 0 | 0 | ||||||||
| Total | 12 | 12/12 | 0/12 | 9/12 | 0/12 | ||||||||||
| Pancreas | |||||||||||||||
| Adenocarcinoma | 8 | ++ | − | + | − | 1 | ++ | + | + | + | 1 | + | +/− | + | − |
| Neuroendocrine tumors | 4 | + | − | − | − | 1 | +++ | − | +++ | − | 1 | ++ | − | +++ | − |
| Metastases of melanoma | 1 | + | − | − | − | 0 | 0 | ||||||||
| Total | 13 | 13/13 | 0/13 | 8/13 | 0/13 | 2 | 2/2 | ½ | 2/2 | 1/2 | 2 | 2/2 | 0/2 | 2/2 | 0/2 |
| Lung | |||||||||||||||
| Adenocarcinoma | 7 | + | − | + | +/− | 0 | 0 | ||||||||
| Squamocellular carcinoma | 8 | ++ | +/− | + | − | 0 | 0 | ||||||||
| Large-cell carcinoma | 2 | + | − | +/− | − | 0 | 0 | ||||||||
| Mesothelioma | 1 | + | ++ | ++ | − | 1 | ++ | +++ | ++ | + | 1 | +/− | +++ | ++ | +/− |
| Metastases of colon adenocarcinoma | 1 | + | − | + | − | 0 | 0 | ||||||||
| Total | 19 | 19/19 | 1/19 | 17/19 | 0/19 | 1 | 1/1 | 1/1 | 1/1 | 1/1 | 1 | 0/1 | 1/1 | 1/1 | 0/1 |
| Stomach | |||||||||||||||
| Gastric adenocarcinoma | 3 | + | + | − | − | 3 | ++ | ++ | +/− | − | 3 | ++ | ++ | +/− | − |
| Total | 3 | 3/3 | 3/3 | 0/3 | 0/3 | 3 | 3/3 | 3/3 | 0/3 | 0/3 | 3 | 3/3 | 3/3 | 0/3 | 0/3 |
| Kidney | |||||||||||||||
| Clear cell carcinoma | 14 | +++ | ++ | − | − | 0 | 0 | ||||||||
| Papillary cell carcinoma | 2 | + | +/− | +/− | − | 0 | 0 | ||||||||
| Adenocarcinoma | 1 | − | ++ | +/− | − | 0 | 0 | ||||||||
| Oncocytoma | 1 | + | − | − | − | 0 | 0 | ||||||||
| Urothelial carcinoma of pelvis | 1 | + | − | +/− | + | 0 | 0 | ||||||||
| Total | 19 | 18/19 | 15/19 | 0/19 | 1/19 | ||||||||||
| Corticoadreno gland | |||||||||||||||
| Surrenal carcinoma | 1 | + | − | − | − | 0 | 0 | ||||||||
| Total | 1 | 1/1 | 0/1 | 0/1 | 0/1 | ||||||||||
| Soft tissues | |||||||||||||||
| Solitary fibrous tumor | 1 | + | − | − | − | 2 | ++ | − | − | − | 2 | + | − | − | − |
| Sarcoma | 1 | ++ | − | + | − | 2 | ++ | − | + | − | 2 | ++ | − | + | − |
| Liposarcoma | 2 | ++ | − | +/− | − | 3 | ++ | +/− | + | − | 3 | + | +/− | +/− | − |
| Osteosarcoma | 1 | ++ | − | ++ | +/− | 1 | ++ | +/− | ++ | + | 1 | ++ | − | ++ | + |
| Angiomyolipoma | 1 | + | − | − | − | 1 | + | − | − | − | 1 | + | − | − | − |
| pNET | 1 | +++ | − | − | − | 1 | +++ | − | +/− | − | 1 | ++ | − | − | − |
| Total | 7 | 7/7 | 0/7 | 2/7 | 0/7 | 10 | 10/10 | 0/10 | 6/10 | 1/10 | 10 | 10/10 | 0/10 | 3/10 | 1/10 |
| Thyroid | |||||||||||||||
| Papillary carcinoma | 1 | ++ | + | + | − | 1 | + | + | ++ | − | 1 | + | + | + | − |
| Total | 1 | 1/1 | 1/1 | 1/1 | 0/1 | 1 | 1/1 | 1/1 | 1/1 | 0/1 | 1 | 1/1 | 1/1 | 1/1 | 0/1 |
| Nervous system | |||||||||||||||
| Glioblastoma | 1 | ++ | − | +/− | − | 2 | +++ | − | +/− | − | 2 | +++ | − | +/− | − |
| Paraganglioma | 1 | ++ | − | ++ | − | 2 | ++ | +/− | + | − | 2 | + | − | + | − |
| Total | 2 | 2/2 | 0/2 | 1/2 | 0/2 | 4 | 4/4 | 0/4 | 2/4 | 0/4 | 4 | 4/4 | 0/4 | 2/4 | 0/4 |
| Total | 101 | 99/101 | 24/101 | 59/101 | 9/101 | 24 | 24/24 | 6/24 | 15/24 | 3/24 | 24 | 23/24 | 5/24 | 12/24 | 1/24 |
| % | (98.0) | (23.8) | (58.4) | (8.9) | (100) | (25.0) | (62.5) | (12.5) | (95.8) | (20.8) | (50.0) | (4.2) | |||