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CLDN18 expression in nonneoplastic pancreas and PanINs. (A-D) Nonneoplastic pancreas. Normal pancreatic ducts ([A] H&E staining; [B] CLDN18 immunostaining) and ductal metaplasia of acinar cells ([C] H&E; [D] CLDN18) do not express claudin-18. (E, F) PanINs. In the PanIN-1 lesion, CLDN18 is strongly expressed in the basolateral membrane ([E] H&E; [F] CLDN18). In the PanIN-3 lesion, CLDN18 is still expressed, but its intensity is weak ([G] H&E; [H] CLDN18). Bar = 2.0 mm.
