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. 2011 Oct;59(10):942–952. doi: 10.1369/0022155411420569

Figure 2.

Figure 2.

CLDN18 expression in IPMN. (A-D) Gastric-type IPMN. Gastric-type IPMN shows strong immunoreactivity to CLDN18 ([A] H&E; [B] CLDN18). The expression is broader than MUC5AC (C) and MUC6 (D). (E-L) Intestinal-type IPMNs. In an intestinal-type IPMN, CLDN18 is diffusely expressed, whereas intestinal markers (CDX2 and MUC2) are only weakly expressed ([E] H&E; [F] CLDN18; [G] CDX2; [H] MUC2). Another intestinal IPMN showed diffuse expression of intestinal markers with decreased CLDN18 expression ([I] H&E; [J] CLDN18; [K] CDX2; [L] MUC2). Some fractions of the tumor cells showed simultaneous expression of CLDN18 and intestinal markers. Bar = 2.0 mm.