Table 1.
CLDN18 Expression in Normal, Metaplastic, and Neoplastic Pancreatic Ductal Lesions
| CLDN18 |
||
|---|---|---|
| Histology | Positive Rate | Expression Score (3+/ 2+/1+/0) |
| Normal pancreatic duct | Negative | — |
| Ductal metaplasia of acinar cells | Negative | — |
| PanIN | 31/32 (96.8%) | 25/6/0/1 |
| PanIN-1 | 18/19 (94.7%) | 15/3/0/1 |
| PanIN-2 | 9/9 (100%) | 9/0/0/0 |
| PanIN-3 | 4/4 (100%) | 1/3/0/0 |
| IPMN | 61/64 (95.3%) | 37/21/3/3 |
| Low grade | 38/39 (97.4%) | 25/12/1/1 |
| High grade | 23/25 (92.0%) | 12/9/2/2 |
| Gastric type | 44/45 (97.8%) | 31/13/0/1a |
| Intestinal type | 13/15 (86.7%) | 3/8/2/2a |
| Onocytic type | 4/4 (100%) | 3/0/1/0 |
| MCN | 4/5 (80.0%) | 2/2/0/1 |
| PDAC | 109/156 (69.9%) | 45/33/31/47 |
| Well differentiated | 28/31 (90.3%) | 19/7/2/3b |
| Moderately differentiated | 71/98 (72.4%) | 26/23/22/27b |
| Poorly differentiated | 10/27 (37.0%) | 0/1/9/17b |
a
The significant difference was found between gastric-type IPMN and intestinal-type IPMN (p = 0.001).
b
The significant differences were found between well and poorly differentiated carcinomas (p < 0.0001) and between moderately and poorly differentiated carcinomas (p = 0.0002).