Table 2.
Expression of CLDN18, MUC5AC, and MUC6 in PanINs, IPMNs, and MCNs
| No. of Cases |
||||||
|---|---|---|---|---|---|---|
| Total | 3+ | 2+ to 1+ | Negative | |||
| PanIN | PanIN-1 | CLDN18 | 19 | 15 | 3 | 1 |
| MUC5AC | 19 | 5 | 11 | 3 | ||
| MUC6 | 19 | 2 | 14 | 3 | ||
| PanIN-2 | CLDN18 | 9 | 9 | 0 | 0 | |
| MUC5AC | 9 | 3 | 4 | 2 | ||
| MUC6 | 9 | 4 | 4 | 1 | ||
| PanIN-3 | CLDN18 | 4 | 1 | 3 | 0 | |
| MUC5AC | 4 | 1 | 2 | 1 | ||
| MUC6 | 4 | 0 | 3 | 1 | ||
| Gastric IPMN | Low grade | CLDN18 | 32 | 23 | 9 | 0 |
| MUC5AC | 32 | 10 | 19 | 3 | ||
| MUC6 | 32 | 6 | 17 | 9 | ||
| High grade | CLDN18 | 13 | 8 | 4 | 1 | |
| MUC5AC | 13 | 3 | 7 | 3 | ||
| MUC6 | 13 | 1 | 7 | 5 | ||
| Intestinal IPMN | Low grade | CLDN18 | 5 | 0 | 4 | 1 |
| MUC5AC | 5 | 0 | 1 | 4 | ||
| MUC6 | 5 | 0 | 1 | 4 | ||
| High grade | CLDN18 | 10 | 3 | 6 | 1 | |
| MUC5AC | 10 | 0 | 7 | 3 | ||
| MUC6 | 10 | 0 | 3 | 7 | ||
| Oncocytic IPMN | Low grade | CLDN18 | 2 | 2 | 0 | 0 |
| MUC5AC | 2 | 2 | 0 | 0 | ||
| MUC6 | 2 | 2 | 0 | 0 | ||
| High grade | CLDN18 | 2 | 1 | 1 | 0 | |
| MUC5AC | 2 | 1 | 1 | 0 | ||
| MUC6 | 2 | 1 | 0 | 1 | ||
| MCN | CLDN18 | 5 | 2 | 2 | 1 | |
| MUC5AC | 5 | 0 | 4 | 1 | ||
| MUC6 | 5 | 0 | 1 | 4 | ||