Table 2.
Results of morphometry and scoring analysis
| Stain | Group | Mean | Standard Error | Kruskal-Wallis Testp Values | Versus UPp Values | Versus IUPp Values | Versus PUNLMPp Values | Versus LG-UCCp Values |
|---|---|---|---|---|---|---|---|---|
| Results of morphometry | ||||||||
| Claudin-1 | Normal | 13.45 | 1.82 | 0.001* | 1.000 | 0.040* | 1.000 | 1.000 |
| UP | 20.21 | 2.09 | 0.006* | 1.000 | 1.000 | |||
| IUP | 34.95 | 3.74 | 0.047* | 0.002* | ||||
| PUNLMP | 22.74 | 3.14 | 1.000 | |||||
| LG-UCC | 18.65 | 3.46 | ||||||
| Claudin-2 | Normal | 0.44 | 0.15 | 0.104 | 1.000 | 1.000 | 1.000 | 1.000 |
| UP | 1.27 | 0.29 | 1.000 | 1.000 | 0.057 | |||
| IUP | 1.21 | 0.56 | 1.000 | 1.000 | ||||
| PUNLMP | 0.81 | 0.29 | 1.000 | |||||
| LG-UCC | 0.33 | 0.08 | ||||||
| Claudin-4 | Normal | 2.56 | 1.20 | 0.631 | 1.000 | 1.000 | 1.000 | 1.000 |
| UP | 4.77 | 0.77 | 1.000 | 1.000 | 1.000 | |||
| IUP | 3.92 | 1.02 | 1.000 | 1.000 | ||||
| PUNLMP | 4.11 | 0.51 | 1.000 | |||||
| LG-UCC | 4.03 | 0.66 | ||||||
| Claudin-7 | Normal | 0.284 | 0.094 | 0.162 | 1.000 | 1.000 | 1.000 | 0.620 |
| UP | 0.15 | 0.06 | 1.000 | 1.000 | 1.000 | |||
| IUP | 0.24 | 0.10 | 1.000 | 1.000 | ||||
| PUNLMP | 0.21 | 0.09 | 0.720 | |||||
| LG-UCC | 0.07 | 0.05 | ||||||
| Results of scoring analysis | ||||||||
| Claudin-1 | Normal | 6.00 | 1.155 | 0.002* | 1.000 | 0.047* | 1.000 | 1.000 |
| UP | 8.68 | 0.75 | 0.039* | 1.000 | 1.000 | |||
| IUP | 11.63 | 0.97 | 0.027* | 0.006* | ||||
| PUNLMP | 8.82 | 0.85 | 1.000 | |||||
| LG-UCC | 7.50 | 0.98 | ||||||
| Claudin-2 | Normal | 2.4 | 0.65 | 0.567 | 1.000 | 1.000 | 1.000 | 1.000 |
| UP | 3.52 | 0.59 | 1.000 | 1.000 | 1.000 | |||
| IUP | 3.36 | 0.76 | 1.000 | 1.000 | ||||
| PUNLMP | 3.83 | 0.73 | 1.000 | |||||
| LG-UCC | 2.79 | 0.52 | ||||||
| Claudin-4 | Normal | 3.00 | 0.58 | 0.459 | 1.000 | 1.000 | 1.000 | 1.000 |
| UP | 3.75 | 0.49 | 1.000 | 1.000 | 1.000 | |||
| IUP | 4.27 | 0.73 | 1.000 | 1.000 | ||||
| PUNLMP | 3.62 | 0.47 | 1.000 | |||||
| LG-UCC | 4.89 | 0.62 | ||||||
| Claudin-7 | Normal | 1.67 | 0.33 | 0.096 | 1.000 | 1.000 | 1.000 | 0.164 |
| UP | 0.83 | 0.26 | 1.000 | 1.000 | 1.000 | |||
| IUP | 1.33 | 0.66 | 1.000 | 1.000 | ||||
| PUNLMP | 0.59 | 0.17 | 0.651 | |||||
| LG-UCC | 0.37 | 0.15 | ||||||
| Results of Ki-67 analysis | ||||||||
| Ki-67 | Normal | 2.10 | 1.05 | <0.001* | 1.000 | 1.000 | 0.323 | <0.001* |
| UP | 3.27 | 0.41 | 1.000 | 0.038* | <0.001* | |||
| IUP | 5.37 | 1.55 | 0.223 | <0.001* | ||||
| PUNLMP | 9.27 | 1.87 | 0.621 | |||||
| LG-UCC | 17.88 | 2.87 | ||||||
Note: Mean and standard error values are listed together with comparisons of the protein expression between normals, UPs, IUPs, PUNLMPs, and LG-UCCs. Horizontal groups were compared with vertical groups using the Kruskal-Wallis test. Significant changes (p < 0.05) are marked with an asterisk (*). UP = urothelial papilloma; IUP = inverted urothelial papilloma; PUNLMP = papillary urothelial neoplasm of low malignant potential; LG-UCC = low-grade urothelial cell carcinoma.