Figure 6.

Lymphatic vessel endothelial hyaluronan receptor–1 (LYVE-1) expression is reduced in lymphatic vessels of dystrophin-deficient mdx muscles and normal muscles regenerating after cardiotoxin injury. Quadriceps muscles from 3-week-old (A, B) or 4-week-old (C, D) mice were immunostained for LYVE-1 expression. At 3 weeks, LYVE-1 expression in lymphatic vessels of affected mdx muscle (B) appeared similar to that of unaffected sibling muscle (A). At 4 weeks, mdx muscle undergoing degeneration and regeneration (D) had reduced LYVE-1 expression compared with unaffected sibling muscle (C). Regenerating tibialis anterior muscle of normal C57BL/6 mice 5 days after cardiotoxin injury exhibited reduced LYVE-1 (E) and elevated tenascin C levels (F) in regions of tissue damage and regeneration (double immunostained sample). *MyoD-hBcl-2 tg(+). (Scale bars=100 µm.)