Skip to main content
. 2011 Oct 24;208(11):2217–2223. doi: 10.1084/jem.20111266

Figure 2.

Figure 2.

The C. trachomatis plasmid-cured trachoma strain A2497P− is highly attenuated for the monkey eye. (A) Six monkeys were infected with A2497 (individual data points are plotted). These monkeys are six historic controls from two recent nonhuman primate studies (Kari et al., 2008, 2009; the information in Fig. 2 A is reprinted with permission from the Journal of Immunology and the Journal of Infectious Diseases). (B) Six monkeys were infected with A2497P− (individual data points are plotted). RML 145 received 2 × 104 IFU/eye, RML 641 received 2 × 105 IFU/eye, and RML 642, 643, 647, and 147 received 2 × 106 IFU/eye. Day 0 indicates the time of infection of each animal. Chlamydial burden is the geometric mean of recoverable IFU for both eyes of individual monkeys monitored by culture from conjunctival swabs. Clinical disease score is the aggregate clinical score (hyperemia and follicle formation) for both eyes of individual monkeys. The experiment was done once.