Table 1.

Induction of Senescence after REV3 Inhibition Is Dependent on p53 Level.

p53	Cell Line	Mock	shSCR	shREV3	t test shSCR/shREV3
+	IL45	2.3 ± 0.7	2.8 ± 1.0	44.2 ± 4.0	*
+	A549	5.8 ± 0.7	6.0 ± 1.4	16.1 ± 2.3	*
-	A549 shP53	1.0 ± 0.3	0.9 ± 0.3	0.9 ± 0.3	NS
-	MDA-MB-231	0	0	0	N/A
+	AD293 (normal)	0	0	0	N/A

Three independent experiments were analyzed for all cell lines. Shown are means (%) of senescent cells ± SEM.

N/A indicates not applicable; NS, not significant.

*P < .01%.