Table 3: Health related quality of life domains (mean ±SD) among the included adolescents in relation to presence of sickle cell disease (SCD) and gender.

SF-36 subscales		Males (N=288)				Females (N=94)
	Adolescents with SCD (N=136)	Adolescents without SCD (N=152)	Effect size Cohen’s d	P value	Adolescents with SCD (N=44)	adolescents without SCD (N=50)	Effect size Cohen’s d	P value
Physical functioning	59.96±21.23	79.48±24.27	-0.856	0.001	53.41±18.58	84.67±17.95	-1.711	0.001
Role physical	20.65±32.94	79.10±31.84	-1.804	0.001	30.68±35.30	60.83±40.83	-0.789	0.001
Role emotional	43.72±42.77	55.23±40.69	-0.275	0.061	48.82±12.93	42.89±27.90	0.273	0.199
Bodily pain	35.33±28.66	82.97±19.00	-1.959	0.001	28.75±21.72	71.50±24.68	-1.838	0.001
Vitality	46.59±18.86	57.12±16.12	-0.600	0.001	46.25±15.33	41.00±19.63	0.289	0.201
General health	39.02±22.96	68.72±13.67	-1.571	0.001	33.07±18.37	55.83±15.49	-1.339	0.001
Emotional well-being	55.51±18.62	63.33±17.35	-0.435	0.001	48.81±12.93	48.93±19.19	-0.007	0.975
Social functioning	45.10±25.75	64.84±18.13	-0.435	0.001	43.69±21.55	47.83±23.83	-0.182	0.449

SD=Standard Deviation