Table 1.
Age |
Mecp2+/+ |
Mecp2+/− |
||||
---|---|---|---|---|---|---|
Young (26–30 d) |
Adult (250–812 d) |
Young (27–30 d) |
Adult (270–519 d) |
|||
Mecp2 | + | + | + | − | + | − |
Capacitance (pF) | 31.7 ± 1.0 (41) | 24.7 ± 0.5° (127) | 31.9 ± 1.3 (26) | 26.4 ± 1.8*‡(20) | 25.1 ± 1.1° (32) | 18.9 ± 1.5*‡° (18) |
Resistance (MΩ/pF) | 6.7 ± 0.3 (41) | 9.9 ± 0.5° (82) | 8.8 ± 0.8 (26) | 11.5 ± 1.1* (20) | 9.2 ± 0.7 (32) | 18.5 ± 2.0*‡° (18) |
Number of processes | 13.3 ± 0.5 (25) | 10.4 ± 0.5° (25) | 13.0 ± 0.6 (23) | 10.2 ± 0.6*‡ (19) | 10.4 ± 0.4° (30) | 9.6 ± 0.5 (16) |
Length of processes (μm) | 110.5 ± 6.0 (25) | 108.7 ± 4.8 (25) | 103.8 ± 6.2 (23) | 101.3 ± 5.3 (19) | 104.0 ± 5.5 (30) | 81.9 ± 5.8*‡° (16) |
Total length of processes (μm) | 1453 ± 83 (25) | 1132 ± 84° (25) | 1353 ± 99 (23) | 1012 ± 64*‡ (19) | 1074 ± 61° (30) | 792 ± 78*‡° (16) |
Dopamine current density (pA/pF) | 8.1 ± 0.4 (39) | 7.7 ± 0.3 (111) | 7.8 ± 0.4 (26) | 7.0 ± 0.5 (19) | 7.0 ± 0.5 (29) | 5.0 ± 0.7*‡° (17) |
Boldface designates statistical significance. The number of cells is shown in parentheses.
*Statistical significance compared to age-matched wild type.
‡Statistical significance compared to age-matched HET+.
°Statistical significance compared to young age within genotype.