Table 3.

Functional analysis of the 96 probesets (90 genes) differentially expressed between lacunar and non-lacunar stroke. The associated functional and canonical pathways that were represented greater than expected by chance (p<0.05, Fisher’s exact test) are shown, along with the genes expressed in the listed pathways. The majority of pathways represent alterations in immune cells in the blood of patients with lacunar stroke that are different from non-lacunar stroke patients.

	Pathway	Genes	p-value
Canonical Pathways	Innate and Adaptive Immune Cell Communication	CCL3, CCL4, HLA-DRB4, IGHA1, IL8	4.8 ×10−5
	TREM1 Signaling	CCL2, CCL3, IL8	3.2 ×10−3
	T Helper Cell Differentiation	HLA-DQA1, STAT1, TBX21	4.9 ×10−3
	CCR5 Signaling in Macrophages	CALM1, CCL3, CCL4	5.6 ×10−3
	Role Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis	CALM1, CCL2, CSF1, IL8, IL18RAP, SOCS1	6.6 ×10−3
Molecular Functions	Growth of Myeloid Cells & Leukocytes	CCL2, CCL3, CSF1, ERBB2, IL8, LAG3, PML, SOCS1	3.6 ×10−9
	Monocyte & Leukocyte Activation and Recruitment	CCL2, CCL3, CCL4, CSF1, HLA-DQA1, IL8, RUNX3, SPON2, STAT1, UTS2	1.9 ×10−6
	Immune Response	CCL2, CCL3, CCL4, CSF1, ERBB2, HLA-DQA1, HLA-DRB4, IL8, IL18RAP, LAG3, SOCS1, SPON2, STAT1, STK17B, TBX21, TGFBR3	2.2 ×10−5
	Cardiovascular process of blood vessel, endothelial adhesion	BTG1, CCL2, CCL3, IL8, PML, RUNX3, STK4, STX7, TGFBR3, UTS2	9.5×10−4
	Angiogenesis of endothelial cells	ERBB2, IL8	2.2 ×10−3