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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Hepatology. 2011 Oct;54(4):1157–1166. doi: 10.1002/hep.24541

Fig. 4. Viral replication capacity of the rare mutants R2937S, R2937G, and R2937G/I2940T can be restored by mutations E2875K and P2881L/Q.

Fig. 4

Replication levels of the wild-type subgenomic replicon, a replication deficient mutant (GND), mutants containing the rare escape mutations alone (R2937G, upper panel; R2937G/I2940T, middle panel; R2937S, lower panel), or in combination with mutations at position 2875 and/or 2881 were compared. Replication of the wild-type was set 100%. Means and standard errors of three individual experiments are shown. P values comparing replication of mutants and wild-type were calculated by paired t test and are indicated as follows: * P<0.05, ** P<0.005, and *** P<0.0005.