Effect of bio-artificial liver treatment on animal survival in fulminant hepatic failure rats. (A) Survival curves of no-cell, rat AdIL-Ra(−), no-cell rIL-1Ra(+), and rat AdIL-1Ra(+). (B) Survival curves of no-cell and TTNT AdIL-1Ra(+). Rat AdIL-1Ra(−), co-cultured rat hepatocytes with no transfection; no-cell rIL-1Ra(+), bioreactor without cells, but recombinant human IL-1Ra was continuously infused from a venous line; rat AdIL-1Ra(+), co-cultured rat hepatocytes transfected with adenoviral vector encoding human IL-1Ra; TTNT AdIL-1Ra(+), TTNT cells transfected with adenoviral vector encoding human IL-1Ra. IL-1Ra, interleukin-1 receptor antagonist; GalN, D-galactosamine; BAL, bio-artificial liver.