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. Author manuscript; available in PMC: 2011 Oct 25.
Published in final edited form as: N Engl J Med. 2009 Aug 5;361(11):1058–1066. doi: 10.1056/NEJMoa0903840

Figure 2. Allele Frequency in Tumor DNA, Tumor Complementary DNA, and Skin DNA.

Figure 2

Panel A shows the percentage of variant alleles that were detected in tumor DNA, tumor complementary DNA (cDNA), and skin DNA for the 10 validated nonsynonymous tier 1 somatic mutations in the index patient. For comparison, variant allele frequencies are shown for six known single-nucleotide polymorphisms (SNPs). The patient was homozygous for the reference sequence for the first two variants, heterozygous for the next two variants, and homozygous for a rare SNP for the last two variants. Panel B shows variant allele frequencies for all validated tier 1 and tier 2 mutations and the six control SNPs for tumor DNA and skin DNA.