Table 3.
Characteristics of the Patients, According to IDH1 Genotype.*
| Variable | Without IDH1 Mutation (N = 172) | With IDH1 Mutation (N = 16) | P Value |
|---|---|---|---|
| Age at study entry — yr | 46.3±15.8 | 48.9±15.4 | 0.52† |
| Race — no. (%)‡ | 0.88§ | ||
| White | 140 (81) | 13 (81) | |
| Black | 14 (8) | 1 (6) | |
| Other | 18 (10) | 2 (12) | |
| Male sex — no. (%) | 101 (59) | 9 (56) | 1.00§ |
| Bone marrow blasts at diagnosis — % | 69.3±18.1 | 76.7±16.4 | 0.12† |
| Cytogenetic profile — no. (%) | 0.001§ | ||
| Normal | 67 (39) | 13 (81) | |
| Other | 105 (61) | 3 (19) | |
| Cytogenetic risk group — no./total no. (%) ¶ | 0.001§ | ||
| Favorable | 58/169 (34) | 0/16 | |
| Intermediate or normal | 97/169 (57) | 16/16 (100) | |
| Poor | 14/169 (8) | 0/16 | |
| AML-M3 subtype — no. (%) | 40 (23) | 0/16 | 0.03§ |
| Underwent transplantation — no. (%) | 27 (16) | 3 (19) | 0.72§ |
| Mutation — no. (%) | |||
| NPM1 | 36 (21) | 7 (44) | 0.06§ |
| FLT3 | |||
| Internal tandem duplication | 36 (21) | 4 (25) | 0.75§ |
| D835 | 10 (6) | 1 (6) | 1.00§ |
| RAS | 19 (11) | 1 (6) | 1.00§ |
*
Plus–minus values are means ±SD. Percentages may not total 100 because of rounding. AML-M3 denotes acute promyelocytic leukemia, FLT3 FMS-related tyrosine kinase 3, and IDH1 isocitrate dehydrogenase 1.
†
The P value was calculated with the use of the two-sided t-test.
‡
Race was self-reported.
§
The P value was calculated with the use of Fisher’s exact test.