Table 2.

Test characteristics of single and double FIT sampling for detection of screen relevant neoplasia

	Single FIT		"one of two FITs+"		"two of two FITs+"		"mean of two FITs+"
Cut-off value	Sens	Spec	Sens	Spec	Sens	Spec	Sens	Spec
Cut-off 50	47, 6%	88, 2%	54, 0%	83, 0%	43, 5%	93, 2%	52, 4%	88, 8%
N	59/124	844/957	67/124	794/957	54/124	892/957	65/124	850/957
(CI)	(39-57)	(86-90)	(45-63)	(80-85)	(35-53)	(91-95)	(43-61)	(87-91)
Cut-off 75	46, 0%	90, 5%	52, 4%	87, 4%	41, 1%	94, 4%	46, 8%	91, 3%
N	57/124	866/957	65/124	836/957	51/124	903/957	58/124	874/957
(CI)	(37-55)	(88-92)	(43-61)	(85-89)	(32-50)	(93-96)	(38-56)	(89-93)
Cut-off 100	45, 2%	92, 5%	51, 6%	89, 8%	39, 5%	95, 5%	44, 4%	92, 8%
N	56/124	885/957	64/124	859/957	49/124	914/957	55/124	888/957
(CI)	(36-54)	(91-94)	(42-61)	(88-92)	(31-49)	(94-9s7)	(35-54)	(91-94)
Cut-off 150	42, 7%	94, 6%	47, 6%	92, 2%	35, 5%	96, 8%	38, 7%	94, 1%
N	53/124	905/957	59/124	882/957	44/124	926/957	48/124	901/957
(CI)	(34-52)	(93-96)	(39-57)	(89-93)	(27-45)	(95-98)	(30-48)	(92-96)
Cut-off 200	37, 9%	95, 1%	41, 9%	93, 2%	34, 7%	97, 5%	37, 1%	96, 1%
N	47/124	910/957	52/124	892/957	43/124	933/957	46/124	920/957
(CI)	(29-47)	(94-96)	(39-57)	(91-95)	(26-44)	(96-98)	(29-46)	(95-97)

Test characteristics at different cut-off values (ng/ml) of single and three strategies of double FIT sampling for detection of screen relevant neoplasia in 1081* individuals referred for colonoscopy (SRN in 124, no AA nor CRC in 957). *15 cases of late stage CRC were excluded since they were not considered screen relevant.

FIT = faecal immunochemical test, SRN = screen relevant neoplasia, AA = advanced adenoma, CRC = colorectal cancer, "one of two FITs+" = at least one of both FITs above the cut-off value, "two of two FITs+" = both FITs above the cut-off value, "mean of two FITs+" = geometric mean of both FITs above the cut-off value, CI = confidence interval, sens = sensitivity, spec = specificity