Table 3.

Comparison of sensitivity of single and double FIT sampling for screen relevant neoplasia, at fixed specificities

	Single FIT		"one of two FITs+"			"two of two FITs+"			"mean of two FITs+"
Spec	Sens	Cut-off	Sens	Cut-off	p-value	Sens	Cut-off	p-value	Sens	Cut-off	p-value
85%	51, 6%	34	53, 2%	59	1	n.a.*	n.a.*	n.a.*	53, 2%	40	1
90%	46, 0%	73	51, 6%	103	0, 07	44, 4%	27	0, 687	50, 8%	60	0, 125
95%	38, 7%	184	37, 9%	371	1	41, 1%	91	0, 453	37, 9%	159	1

Corresponding cut-off values (ng/ml) and sensitivities for screen relevant neoplasia of single FIT sampling and three different strategies of double FIT sampling at fixed specificities of 85%, 90% and 95%.

FIT = faecal immunochemical test, "one of two FITs+" = at least one of both FITs above the cut-off value, "two of two FITs+" = both FITs above the cut-off value, "mean of two FITs+" = geometric mean of both FITs above the cut-off value, spec = specificity, sens = sensitivity, cut-off = cut-off value, n.a.* = no corresponding sensitivity and cut-off value found in the range 50-200 ng/ml