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. Author manuscript; available in PMC: 2011 Oct 25.
Published in final edited form as: J Med Chem. 2011 Jan 25;54(5):1421–1429. doi: 10.1021/jm101443u

Figure 1.

Figure 1

Initial electron density. (a) Electron density map, 2|Fo| − |Fc|, 1σ (purple), calculated after initial rigid body refinement but before the inclusion of PYR. Difference density (|Fo| − |Fc|) has been drawn in green (2.5σ) and orange (−2.5σ). (b) Structure of pyrimethamine. Atom numbering is the same as that found in PDB code 2BL9.14