Figure 7.

PYR binding site DHFR vs HexB. The overall secondary structures of the molecules have been drawn in blue (a, DHFR) and green (b, HexB). Residues and water molecules near the PYR binding site have been depicted as ball and stick. The NADPH molecule and the active site of DHFR have also been included as ball and stick. Hydrogen bonding interactions are indicated by dashed lines. Coordinates for DHFR are from PDB code 2BL9.¹⁴