Figure 10.

Immunohistochemical localization of annexin in human gliomas. S (Stony Brook Cohort): A, normal cerebellum; B–D, grade I astrocytoma (pilocytic astrocytoma); E, grade II astrocytoma; F, grade III astrocytoma (anaplastic astrocytoma); G–J, Grade IV astrocytoma (GBM). Quantification of annA2 expression is shown below the panels (^#p = 0.01). W (Weill Cornell Medical Center cohort): A, B, Placenta control; C, D, benign pilocytic astrocytoma (patient age, 2 years; sex, male); E, F, high-grade astrocytoma (patient age, 61 years; sex, male); G–L, highly invasive glioblastoma multiforme (G, H: patient age, 80 years: sex, female; I, J: patient age, 66 years; sex, male; K, L: patient age, 74 years; sex, female). Sections were stained with monoclonal anti-annexin A2 (A, C, E, G, I, K) or non-immune IgG (NI; B, D, F, H, J, L). Scale bar, 200 μm.