Figure 4.

Knockdown of annexin A2 on glioma cell impairs tumor progression in vivo, but lack of annexin A2 in stromal cells has no effect on glioma growth. A, Tumor volumes were measured at 10, 15, and 20 d after tumor cell injection (n = 8, from 4 independent injections). B, Kaplan–Meier survival curves of tumor-bearing mice (p = 0.0003, n = 10). Tumor size (C) and MVD (D) were measured 15 d after tumor injection into wt and annA2KO mice (wt mice: tumor size, n = 8; MVD, n = 5; annA2 KO mice: n = 2).