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. 2011 Oct 25;343:d6423. doi: 10.1136/bmj.d6423

Table 3.

 Relative risk of venous thromboembolism among current users of oral contraceptives and hormone releasing intrauterine device according to certainty of diagnosis of venous thromboembolism, with non-users of hormonal contraception as reference group

Product type Women years Anticoagulation (confirmed) Not recorded
No of events* Adjusted relative risk† (95% CI) No of events* Adjusted relative risk† (95% CI) % confirmed
Non-use 4 960 730 1004 1 (reference) 808 1 (reference) 55.4
Progestogen with 50 µg ethinylestradiol:
 Norethisterone 6848 7 6.24 (2.95 to 13.2) 4 5.10 (1.90 to 13.7) 63.6
 Levonorgestrel 23 691 22 4.49 (2.94 to 6.85) 9 2.34 (1.21 to 4.52) 71.0
Progestogen with 30-40 µg ethinylestradiol:
 Norethisterone 27 355 8 2.24 (1.12 to 4.51) 2 0.73 (0.18 to 2.91) 80.0
 Levonorgestrel phasic 105 970 66 3.09 (2.41 to 3.97) 23 1.31 (0.86 to 1.98) 74.2
 Levonorgestrel combined 104 251 57 2.92 (2.23 to 3.81) 21 1.30 (0.84 to 2.00) 73.1
 Norgestimate 267 664 119 3.52 (2.90 to 4.27) 46 1.44 (1.07 to 1.95) 72.1
 Desogestrel 170 249 168 6.61 (5.60 to 7.80) 33 1.43 (1.01 to 2.04) 83.6
 Gestodene 668 355 575 6.24 (5.61 to 6.95) 163 1.92 (1.61 to 2.28) 77.9
 Drospirenone 286 859 196 6.37 (5.43 to 7.47) 70 2.32 (1.80 to 2.98) 73.7
 Cyproterone 120 934 88 6.35 (5.09 to7.93) 21 1.58 (1.02 to 2.44) 80.7
Progestogen with 20 µg ethinylestradiol:
 Desogestrel 470 982 246 4.81 (4.15 to 5.56) 76 1.52 (1.19 to 1.94) 76.4
 Gestodene 472 118 240 5.07 (4.37 to 5.88) 81 1.72 (1.36 to 2.19) 74.8
 Drospirenone 23 055 16 6.95 (4.21 to 11.5) 7 2.58 (1.22 to 5.46) 69.6
Progestogen only:
 Norethisterone 44 168 6 0.68 (0.30 to 1.51) 3 0.41 (0.13 to 1.28) 66.7
 Desogestrel 29 187 3 0.61 (0.20 to 1.90) 3 0.63 (0.20 to 1.97) 50.0
 Levonorgestrel releasing intrauterine device 155 149 26 0.72 (0.49 to 1.06) 29 0.95 (0.65 to 1.38) 47.3

*Events are venous thromboembolisms.

†Adjusted for age, calendar year, and level of education.