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. 2011 Oct 25;343:d6423. doi: 10.1136/bmj.d6423

Table 5.

 Rate ratio of confirmed venous thromboembolism between different combined oral contraceptives with adjustment for length of use

Product group Women years No of events* Adjusted rate ratio† (95% CI) P value
Progestogen with 30-40 μg ethinylestradiol:
 Norethisterone 27 355 8 0.76 (0.36 to 1.60) 0.47
 Levonorgestrel phasic 105 970 66 1.07 (0.75 to 1.52) 0.71
 Levonorgestrel combined 104 251 57 1 (reference)
 Norgestimate 267 664 119 1.18 (0.86 to 1.62) 0.30
 Desogestrel 170 249 168 2.24 (1.65 to 3.02) <0.001
 Gestodene 668 355 575 2.12 (1.61 to 2.78) <0.001
 Drospirenone 286 859 196 2.09 (1.55 to 2.82) <0.001
 Cyproterone 120 934 88 2.11 (1.51 to 2.95) <0.001
Progestogen with 20 μg ethinylestradiol:
 Desogestrel 470 982 246 1.60 (1.20 to 2.14) 0.0015
 Gestodene 472 118 240 1.70 (1.27 to 2.27) 0.0004
 Drospirenone 23 055 16 2.22 (1.27 to 3.89) 0.005

*Events are venous thromboembolisms.

†Adjusted for age, calendar year, level of education, and length of use.