Table 3.
Discrimination and Reclassification for the Comparison of Models including HbA1c to Classification of Diabetes as a Cardiovascular Risk Equivalent in Diabetic Participants
| ATP III | RRS | |
|---|---|---|
| Women’s Health Study | ||
| C-statistic for Risk Equivalent | 0.515 | 0.519 |
| C-statistic for model with HbA1c | 0.692 | 0.697 |
| P value for C-statistic comparison | <0.001 | <0.001 |
| NRI (p value) | 26.7% (0.001) | 23.6% (0.003) |
| IDI (p value) | 0.072 (<0.001) | 0.072 (<0.001) |
| Reclassification χ2 for Risk Equivalent (p value) | 37.6 (<0.001) | 35.9 (<0.001) |
| Reclassification χ2 for model with HbA1c (p value) | 14.4 (0.002) | 15.9 (0.001) |
| Physician’s Health Study II | ||
| C-statistic for Risk Equivalent | 0.563 | 0.578 |
| C-statistic for model with HbA1c | 0.602 | 0.605 |
| P value for C-statistic comparison | 0.015 | 0.081 |
| NRI (p value) | 9.2 % (0.042) | 12.4 % (0.005) |
| IDI (p value) | 0.039 (<0.001) | 0.041 (<0.001) |
| Reclassification χ2 for Risk Equivalent (p value) | 26.5 (<0.001) | 27.1 (<0.001) |
| Reclassification χ2 for model with HbA1c (p value) | 9.8 (0.002) | 6.5 (0.011) |
ATP III = base covariates from Adult Treatment Panel III, RRS = base covariates from Reynolds risk score