Table 3.
Effect of Insulin Treatment on Reversal of Neuronal Pathology in Akita Mouse Prevertebral Sympathetic Ganglia
| Experimental Group | Neuron Number | Degenerating Neuron Frequency |
|---|---|---|
| (neurons/ganglion) | (%) | |
| Saline Treated Akita (n=7) | 8015 ± 775 | 0.96 ± 0.26a |
| Insulin Treated Akita (n=5) | 6954 ± 836 | 0.03 ± 0.03b |
| Saline Treated Controls (n=7) | 5903 ± 667 | 0 ± 0 |
| Akita (2 Month Diabetic = starting point of treatment) (n=5) | --- | 2.2 + 0.4 (plastic sections) |
Values represent the means ± SEM of n mice.
Statistical Comparison:
a
p≤0.01 vs. control
b
p≤0.01 vs. saline-treated Akita