Table 4.
Effect of ARA290 Treatment on Reversal of Neuronal Pathology in Akita Mouse Prevertebral Sympathetic Ganglia
| Experimental Group | Neuron Number | Degenerating Neuron Frequency |
|---|---|---|
| (neurons/ganglion) | (%) | |
| Saline Treated Akita (n=6-7) | 4435 ± 692b | 2.1 ± 0.4a |
| ARA290 Treated Akita (n=8) | 4373 ± 724a | 1.5 ± 0.1a |
| Combined Saline & ARA290 Treated Controls (n=8-10) | 8442 ± 729 | 0.04 ± 0.01 |
| Akita - 4 month Diabetic (starting point for Rx) (n=4) | --- | 7.0 ± 1.3 (plastic section data) |
Values represent the means ± SEM of n mice.
Statistical Comparison:
a
p≤0.001
b
p<0.01 vs. control