Table 1.
γ-H2AX-IRIF comparison with the CSA
| Cell Line | 24 Hour1 | Formation2 | Resolution3 | Combined |
|---|---|---|---|---|
| WT2 | N | N | N | N |
| A-T | N | D | D | D |
| NBS | N | D | D | D |
| LigIV | N | D | D | D |
| PNKP | N | N | D | D |
| RNF168 | D | N | D | D |
| RS36 | N | N | D | D |
| RS73 | N | D | D | D |
| RS70 | N | D | D | D |
| RS39 | N | N | N | N |
| RS26 | N | D | N | D |
| RS100 | N | D | D | D |
| RS29 | D | N | D | D |
| RS37 | D | N | N | N |
| Concordance With CSA (%) | 27 | 60 | 80 | 87 |
| Regression Slope | −0.04 | 2.25 | 0.008 | NA |
| P-value | 0.79 | 0.001 | 0.001 | NA |
| Correlation Coefficient | 0.005 | 0.54 | 0.54 | NA |
N: Normal compared to WT1 daily control.
D: Defective. Values outside of WT range (WT1 daily control).
Previously used single time point IRIF technique (24 hour post-IR).
Formation of IRIF constant from fit function.
Resolution of IRIF constant from fit function.