Table 3.

Carotid Artery Intima-Media Thickness Progression Rate by Isoflavone Soy Protein Treatment Group Equol Producer Status versus Placebo Treatment

Study group	N*	CIMT†	p-value‡	p-value§
Placebo-treatment	163	5.68 (4.29–7.07)	Reference	0.84
Isoflavone soy protein-treatment
Non-equol producer	76	5.09 (3.07–7.12)	0.64
Intermittent equol producer	35	4.52 (1.55–7.50)	0.49
Consistent equol producer	39	4.56 (1.74–7.39)	0.49

^*Sample size; isoflavone soy protein treatment group sample size does not total 162 subjects since 12 participants did not have sufficient follow-up equol measures to be classified.

^†Mean (95% confidence interval) carotid artery intima-media thickness change rate in μm/year.

^‡p-value for difference from placebo.

^§Overall p-value across isoflavone soy protein treatment equol producer categories compared to placebo treatment adjusted for CIMT randomization strata.