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Pharmacokinetic parameter estimates for denosumab in healthy postmenopausal women.
| Parameter (units) | Final Estimate | CV% |
|---|---|---|
| ka (day−1) | 0.170 | 2.7 |
| kel (day−1) | 1.15 × 10-2 | 0.554 |
| Vc/F (mL/kg) | 77.9 | 1.55 |
| Km (ng/mL) | 411 | 1.35 |
| Vmax (ng/kg/day) | 2672 a | - |
fixed parameter based on preliminary analysis.
