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Denosumab pharmacodynamic parameter estimates for serum/urine NTX in healthy postmenopausal women (PMW) and urine NTX in postmenopausal women with low bone mineral density, using integrated bone homeostasis model.
| Parameter (units) | Final Estimate | CV% |
|---|---|---|
| Healthy PMW | ||
| DA (day−1) | 9.55 | 17.7 |
| Eb,sNTX (nM) | 7.24 | 4.49 |
| Eb,uNTX(nmol/mmolCr) | 14.4 | 4.67 |
| PMW with low BMD | ||
| DA (day−1) | 9.55 a | - |
| Eb,uNTX(nmol/mmolCr) | 23.0 | 3.40 |
fixed parameter based on fitted biomarker (NTX) data in healthy PMW.
