Table 2.

Results of multivariable Cox regression models with first incident stroke as outcome without and with IMT (intima-media thickness) variables.

	Risk factors		With IMT rate-of-change		With IMT rate-of-change and IMT		With IMT rate-of- change Quartile / IMT		With IMT rate-of- change upper quartile / IMT
Variable	HR	P- Value	HR	P- Value	HR	P- Value	HR	P-Value	HR	P-Value
Age (Years)	1.05	0.04	1.05	0.04	1.05	0.03	1.05	0.02	1.05	0.02
Sex (Male)	0.73	0.40	0.75	0.44	0.75	0.44	0.74	0.45	0.73	0.42
Systolic Pressure (mm/Hg)	1.02	0.0012	1.02	0.0012	1.02	0.00	1.02	0.007	1.02	0.001
Hypertension Medication (Yes)	1.56	0.21	1.57	0.20	1.60	0.19	1.66	0.15	1.63	0.17
LDL Cholesterol (mg/dL)	1.00	0.76	1.00	0.76	1.00	0.70	1.00	0.72	1.00	0.76
HDL Cholesterol (mg/dL)	0.96	0.01	0.96	0.01	0.96	0.01	0.96	0.01	0.96	0.01
Diabetes (Yes)	0.98	0.99	0.94	0.93	0.96	0.95	0.97	0.94	0.99	0.97
Smoking (Yes)	1.49	0.37	1.58	0.30	1.62	0.29	1.60	0.30	1.57	0.31
Education	0.92	0.64	0.91	0.60	0.92	0.65	0.92	0.66	0.92	0.67
Income	0.87	0.49	0.87	0.49	0.87	0.47	0.87	0.47	0.87	0.47
IMT (per SDEV)	.	.	.	.	0.89	0.32	0.91	0.44	0.90	0.36
IMT rate-of-change (per SDEV)	.	.	1.23	0.03	1.29	0.03	.	.	.	.
Q2	.	.	.	.	.	.	1.76	0.29	.	.
Q3	.	.	.	.	.	.	1.88	0.22	.	.
Q4	.	.	.	.	.	.	3.12	0.01	.	.
Q4 as compared to Q1, Q2 and Q3 combined	.	.	.	.	.	.	.	.	2.18	0.03

HR: Hazard Rate Ratio; Whites are the reference for ethnicity; SDEV: standard deviation; Education and total family income as indicated in the Methods section. Quartiles of IMT rate-of-change: Q1 (reference): −0.367, 0.00004 mm/year; Q2: 0.00004, 0.0115 mm/year; Q3: 0.0116, 0.0264 mm/year; Q4: 0.0264, 0.472 mm/year. Results are adjusted for ethnicity.