Table 2.

Univariate Analysis of Risk Factors for Brain Tissue Hypoxia and Metabolic Crisis

	Brain tissue hypoxia		Metabolic crisis
	OR (95% CI)	P value	OR (95% CI)	P value
Demographics
Female	1.63 (0.46–5.71)	0.45	1.88 (0.25–14.35)	0.54
Age, per year	1.00 (0.97–1.04)	0.91	0.98 (0.92–1.03)	0.39
Past Medical History
Hypertension	0.83 (0.29–2.36)	0.73	0.57 (0.09–3.78)	0.56
Diabetes mellitus	2.13 (0.54–8.39)	0.28	2.66 (0.34–21.02)	0.35
Smoking	1.58 (0.45–5.52)	0.47	4.25 (0.71–25.52)	0.11
Baseline Clinical
ICH volume, per ml	0.99 (0.97–1.02)	0.79	1.01 (0.98–1.03)	0.57
IVH volume, per ml	1.00 (0.97–1.04)	0.76	0.93 (0.87–1.00)	0.06
Glasgow coma scale	1.12 (0.80–1.56)	0.50	0.98 (0.85–1.11)	0.34
APACHE-II subscore*	0.95 (0.86–1.04)	0.23	0.95 (0.82–1.09)	0.45
Daily Variables
ICH day	0.90 (0.73–1.11)	0.32	1.06 (0.93–1.20)	0.40
Hourly Variables
CPP, per 10 mm Hg	0.82 (0.69–0.96)	0.014	0.98 (0.90–1.07)	0.71
ICP, per mm Hg	1.02 (0.98–1.07)	0.31	0.99 (0.97–1.01)	0.22
ETCO2, per mm Hg	0.85 (0.78–0.93)	< 0.001	0.95 (0.90–1.01)	0.11
Serum glucose, per mmol/L	1.01 (1.00–1.02)	0.06	1.00 (0.99–1.02)	0.30
PRx > 0.2	3.05 (1.47–6.31)	0.003	0.98 (0.76–1.27)	0.88
ORx > 0.2	0.89 (0.45–1.75)	0.75	1.12 (1.02–1.23)	0.02

OR, odds ratio; CI, confidence interval; CPP, cerebral perfusion pressure; ETCO₂, end tidal carbon dioxide; PRx, pressure reactivity index; ORx, oxygen reactivity index (refer to text for definitions). P values in bold are significant.