Table 2.
Clinical outcomes of patients undergoing multiple Gamma Knife treatments.
| Author (year) | Clinical evaluation method | GKRS max retreatment dose (Gy) | Study endpoints | Results |
|---|---|---|---|---|
| BNI score I | 47.6% | |||
| Gellner et al. [32] (2008) | BNI | Mean: 74.3 | BNI score II | 28.6% |
| BNI score III | 23.8% | |||
|
| ||||
| BNI score I | 34% | |||
| BNI score II | 17% | |||
| BNI score IIIa | 6% | |||
| Huang et al. [29] (2010) | BNI | Mean: 49 | BNI score IIIb | 8% |
| 1-y pain control rate | 74% | |||
| 2-y pain control rate | 71% | |||
| 3-y pain control rate | 66% | |||
| Facial numbness | 17% | |||
|
| ||||
| Excellent pain relief | 46% | |||
| Good pain relief | 24% | |||
| Aubuchon et al. [31] (2010) | EGFP | Mean: 84.4 | Fair pain relief | 14% |
| Poor pain relief | 16% | |||
| Trigeminal nerve dysfunction | 57% | |||
|
| ||||
| Excellent pain relief | 43% | |||
| Huang et al. [28] (2006) | EGFP | Mean: 52 | Good pain relief | 18% |
| Fair pain relief | 7% | |||
| Facial numbness | 36% | |||
|
| ||||
| Marseille class I-II | 43.5% | |||
| Kimball et al. [27] (2010) | Marseille | 70 | Marseille class III-IV | 13% |
| Marseille class V | 43.5% | |||
| Facial numbness | 46% | |||
BNI: Barrow Neurological Institute; EGFP: excellent-good-fair-poor; GKRS: Gamma Knife radiosurgery.