Table 1.

Baseline characteristics of treated patients (n = 56)^a.

Mean age (yr) 42 ± 14

Male sex, n (%) 36 (64.2)

Mean heartburn score 3.8 ± 1.9

Mean HRQL scoreb  29 ± 9

Mean SF-36 mental 40 ± 7

Mean SF-36 physicalc 41 ± 7

Daily PPI use, n (%) 56 (100)

Median 24-h pHd 15.85 (5.9–18.2)

Median LES pressure (mmHg) 8.44 (7.2–11.7)

<2 cm hiatal hernia, n (%) 28 (50)

Erosive esophagitis at EGD, n (%)e 14 (25)

EGD: esophagogastroduodenoscopy; LES: lower esophageal sphincter.

^aMeans report ±1 SD, medians report 25th and 75th percentile ranges, and proportions report absolute numbers (percentiles).

^bHeartburn and heartburn-related quality of life scores (higher scores for worse symptoms).

^cSF-36 physical score (higher scores for better function; U.S. general ‘‘healthy group” population mean = 55.3).

^dPercentage of time esophageal pH was <4 (off antisecretory medications).

^eTen patients with grade A and four patients with grade B esophagitis according to the Los Angeles classification.