Table 3.
Top 20 differentially expressed proteins selected by supervised classification methods for classifying two tumor subtypes.
| Rank | Accession no. | Protein name | MW | HER2+/TNBC mean | Subcellular location | Function |
|---|---|---|---|---|---|---|
| 1 | gi∣10946578 | Thymosin β4 | 5 kDa | 2.99 | Cytoplasm, cytoskeleton | For cytoskeletal binding, involved in cell growth and maintenance |
| 2 | gi∣4507521 | Transketolase | 68 kDa | 4.20 | Cytosol | Involved in metabolism. Associated with cell proliferation of uterine and cervical cancer. |
| 3 | gi∣1633054 | Cyclophilin A | 18 kDa | 2.45 | Cytoplasma | Involved in accelerate the folding of proteins |
| 4 | gi∣73858568 | Complement component 1 inhibitor | 55 kDa | 0.33 | Secreted | Regulating the complement cascade |
| 5 | gi∣4557871 | Transferrin | 77 kDa | 16.38 | Secreted | Essential for cell growth and iron-dependent metabolic processes |
| 6 | gi∣90111766 | Keratin type I cytoskeletal 19 | 44 kDa | 11.29 | Cytoskeleton | Involved in metastatic progression of breast cancer |
| 7 | gi∣10863895 | Thymosin β10 | 5 kDa | 2.25 | Cytoplasm, cytoskeleton | For cytoskeletal binding, involved in cell growth and maintenance |
| 8 | gi∣5031863 | Galectin-3-binding protein | 65 kDa | 0.41 | Secreted | Modulating cell-cell and cell-matrix interactions |
| 9 | gi∣4505753 (+1) | Phosphoglycerate mutase 1 | 29 kDa | 2.51 | Cytosol | Involved in glycolysis |
| 10 | gi∣5174391 | Aldo-keto reductase family 1, member A1 | 37 kDa | 0.30 | Cytosol | Involved in the reduction of biogenic and xenobiotic aldehydes |
| 11 | gi∣21361176 | Aldehyde dehydrogenase 1A1 | 55 kDa | 0.39 | Cytoplasm | Detoxifying enzyme responsible for oxidating of intracellular aldehydes. A marker for cancer stem cells |
| 12 | gi∣4505185 | Macrophage migration inhibitory factor | 12 kDa | 0.36 | Secreted, cytoplasm | Involved in integrin signaling pathways |
| 13 | gi∣4507645 (+2) | Triosephosphate isomerase 1 | 27 kDa | 2.49 | Cytosol, nucleus | Fatty acid biosynthesis, gluconeogenesis, glycolysis, lipid synthesis |
| 14 | gi∣4930167 | Aldolase A | 39 kDa | 6.41 | Extracellular, cytoskeleton | Involved in glycolysis |
| 15 | gi∣116241280 | Adenylyl cyclase-associated protein 1 (CAP 1) | 52 kDa | 3.03 | Membrane | Regulating filament dynamics, cell polarity and signal transduction, |
| 16 | gi∣21624607 (+5) | Coactosin-like 1 | 16 kDa | 0.42 | Cytoplasm, cytoskeleton | Regulating the actin cytoskeleton |
| 17 | gi∣160420317 | Filamin A, alpha isoform 2 | 281 kDa | 3.10 | Cytoplasm | Anchoring transmembrane proteins to the actin cytoskeleton, scaffold for cytoplasmic signaling proteins |
| 18 | gi∣6005942 | Valosin-containing protein | 89 kDa | 3.26 | Cytosol, nucleus | Fragmentation of Golgi stacks during mitosis and reassembly |
| 19 | gi∣5174539 | Cytosolic malate dehydrogenase | 36 kDa | 2.52 | Cytoplasm | Involved glycolysis, oxidation reduction, and tricarboxylic acid cycle |
| 20 | gi∣33286418 (+2) | Pyruvate kinase 3 | 58 kDa | 6 | Cytoplasm, nucleus | Involved in glycolysis |