Effect of BAL treatment on hepatic enzymes in fulminant hepatic failure rats. Aspartate aminotransferase (AST) (a) and alanine aminotransferase (ALT) (b) levels 24 h after hepatitis induction. The results are expressed as means ± SD. *p < 0.05 vs. no cell AdIL-1Ra(–) group. No cell AdIL-1Ra(–), no cells in the BAL device; porcine AdIL-1Ra(–), non-transfected porcine hepatocytes in the BAL device; no cell rIL-1Ra(+), BAL device without cells but recombinant human IL-1Ra was continuously infused through a venous line; porcine AdIL-1Ra(+), porcine hepatocytes transfected with adenoviral vector encoding human IL-1Ra. IL-1Ra, interleukin-1 receptor antagonist; BAL, bioartificial liver.