Table 2.
Correlation between Treg suppressive activity pre- and post-vaccination and CTLA-4 expression on Tregs
| Patients with decreased Treg suppression | Patients with increased Treg suppression | ||||||
|---|---|---|---|---|---|---|---|
| Patients | % CTLA-4+ Tregs | Δ CTLA-4+ Tregs | Patients | % CTLA-4+ Tregs | Δ CTLA-4+ Tregs | ||
| Pre | Post | Post − pre | Pre | Post | Post − pre | ||
| Patients with decreased CTLA-4 + Tregs | Patients with decreased CTLA-4 + Tregs | ||||||
| #6 | 10.0 | 2.5 | −7.5 | #5 | 10.9 | 4.4 | −6.5 |
| #14 | 6.0 | 5.7 | −0.3 | ||||
| #15 | 9.7 | 8.9 | −0.8 | ||||
| #20 | 6.9 | 4.6 | −2.3 | ||||
| #23 | 10.7 | 5.3 | −5.4 | ||||
| #24 | 10.3 | 4.7 | −5.6 | ||||
| #32 | 5.0 | 3.5 | −1.5 | ||||
| Mean | 8.4 | 5.0 | −3.3 | Mean | 10.9 | 4.4 | −6.5 |
| Patients with increased CTLA-4 + Tregs | Patients with increased CTLA-4 + Tregs | ||||||
| #1 | 6.1 | 12.5 | 6.4 | #4 | 6.0 | 10.9 | 4.9 |
| #2 | 7.5 | 13.3 | 5.8 | #12 | 4.9 | 22.6 | 17.7 |
| #11 | 2.8 | 7.3 | 4.5 | #13 | 13.8 | 14.1 | 0.3 |
| #17 | 4.1 | 9.0 | 4.9 | #18 | 4.0 | 12.0 | 8.0 |
| #21 | 3.9 | 5.4 | 1.5 | ||||
| #26 | 10.1 | 11.8 | 1.7 | ||||
| #28 | 11.3 | 14.1 | 2.8 | ||||
| Mean | 5.1 | 10.5 | 5.4 | Mean | 7.7 | 13.0 | 5.3 |
Results are expressed as % of CTLA-4+ Tregs in CD4+CD25+CD127−FoxP3+ Tregs