Figure 5.

Fz receptors mediate Wnt5a induced axon repulsion but not outgrowth, but Ryk receptors mediate both outgrowth and repulsion. (A) Tracings of trajectories of axons exposed to Wnt5a gradients in the presence of sFRP2 showing increased axon outgrowth but not repulsion. (B) Tracings of trajectories of P0 axons exposed to Wnt5a gradients following Ryk knockdown, which prevents increased axon outgrowth as well as repulsion by Wnt5a. (C) Bar graphs quantifying turning angles (top) and outgrowth rates (bottom) of axons in (A) and (B). Scale bar, 5 μm. In all histograms *p < 0.05, **p < 0.01; n.s., not significant. (Reprinted from Li et al., 2009; with permission from the Society for Neuroscience).