Figure 3.

Comparison of gene content in total microbial communities and VLP communities. (A) The proportions of total genes identified in shotgun metagenomic analysis of total stool DNA (left) is compared with genes in VLP communities (right). (B) VLP DNA encodes biochemical functionality that is markedly different from the total microbiome. Function annotation was performed according to comparison to the COG database (Tatusov et al. 2003). The proportion of reads from each assembled data set that fall within an ORF of the indicated annotation are plotted on the x-axis (mean ± SE).