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. 2011 Oct;21(10):1640–1649. doi: 10.1101/gr.124461.111

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Figure 4. — Subterminal heterochromatic cap architecture in chimpanzee and gorilla. (A) Different FISH hybridization patterns using human fosmid probes (ABC8_40868200_C16 and ABC8_40925900_F12) corresponding to one hyperexpanded SD in gorilla (chr10: 19530349-19564732) and one in chimpanzee (chr2: 113978394-114020431). Extracted metaphase chromosomes (top panel) and cohybridization experiments (lower panel) in chimpanzee and gorilla reveal differences in the composition of the heterochromatic cap in each species. (B) Complete sequence analysis of three large-insert BAC clones sampled from gorilla and chimpanzee genomes confirm large-scale differences in the sequence organization. pCht satellite sequence (purple) interdigitates between different SDs (color bars) depending on the species. These SDs have expanded in copy from 500 to 1000 copies (y-axis represents copy number count based on read-depth) in chimpanzee (blue) and gorilla (red). This architecture has emerged in a species-specific fashion in conjunction with the evolution of the subterminal heterochromatic satellite.