Table 1.
Demographic characteristics of subjects with bipolar disorder (BD) (n = 10) and controls (n = 10)
| Paired subjects | Gender/Age (yrs) | Postmortem delay (hrs) | Cause of death | Treatmenta | ||||
|---|---|---|---|---|---|---|---|---|
| BD | Control | BD | Control | BD | Control | BD | Control | |
| 1 | M/72 | M/72 | 22 | 43 | Suicide | Accident | Drug free | Drug free |
| 2 | F/44 | F/49 | 19 | 40 | Suicide | Accident | APS, BZD, mirtazapine | Drug free |
| 3 | M/58 | M/54 | 10 | 23 | Suicide | Accident | APS, lamotrigine | BZD |
| 4 | M/40 | M/43 | 17 | 11 | Suicide | Accident | BZD | Drug free |
| 5 | M/27 | M/30 | 10 | 11 | Suicide | Accident | Drug free | Cannabis |
| 6 | M/63 | M/60 | 8 | 4 | Suicide | Natural | BZD | Drug free |
| 7 | M/64 | M/61 | 23 | 23 | Suicide | Accident | BZD, venlafaxine | Drug free |
| 8 | M/57 | M/55 | 22 | 22 | Natural | Natural | Drug free | Drug free |
| 9 | M/63 | M/67 | 31 | 19 | Natural | Natural | Drug free | NSAID |
| 10 | F/73 | F/74 | 3 | 19 | Suicide | Accident | Drug free | NSAID |
M = male; F = female; APS = antipsychotics; BZD = benzodiazepines; NSAID = nonsteroidal anti-inflammatory drug. BD group (mean ± SD): age: 56 ± 15 yrs; postmortem delay (PMD): 16 ± 9 hrs; pH in the cerebellum (CB): 6.74 ± 0.24; pH in the prefrontal cortex (PFC): 6.59 ± 0.14; RNA integrity number (RIN) in the CB: 7.52 ± 0.46; RIN in the PFC: 6.40 ± 1.03. Control group (mean ± SD): age: 56 ± 14 yrs; PMD: 21 ± 12 hrs; pH in the CB: 6.77 ± 0.26; pH in the PFC: 6.92 ± 0.32; RIN in the CB: 7.90 ± 0.53; RIN in the PFC: 6.85 ± 0.40.
a
Treatment indicates results of toxicology analysis performed by the National Institute of Toxicology, Madrid, Spain.